2-(p-Methoxyphenyl)quinoxaline

Base Information

• Chemical Name: 2-(p-Methoxyphenyl)quinoxaline
• CAS No.: 5021-46-5
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• DSSTox Substance ID: DTXSID10198245
• Nikkaji Number: J1.447.562A
• Wikidata: Q83071020
• Mol file: 5021-46-5.mol

Synonyms:2-(p-Methoxyphenyl)quinoxaline;2-(4-methoxyphenyl)quinoxaline;5021-46-5;Quinoxaline, 2-(p-methoxyphenyl)-;Oprea1_025931;SCHEMBL710433;2-(4-methoxyphenyl) quinoxaline;DTXSID10198245;NSC810179;STL573206;AKOS003342817;NSC-810179

Chemical Property of 2-(p-Methoxyphenyl)quinoxaline

Chemical Property:

• Vapor Pressure: 3.59E-06mmHg at 25°C
• Boiling Point: 397.6°Cat760mmHg
• Flash Point: 132.9°C
• Density: 1.185g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 236.094963011
• Heavy Atom Count: 18
• Complexity: 263

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC3=CC=CC=C3N=C2

Technology Process of 2-(p-Methoxyphenyl)quinoxaline

There total 55 articles about 2-(p-Methoxyphenyl)quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-diamino-benzene (95-54-5) + p-methoxyphenylglyoxal (1076-95-5) → 2-(4-methoxyphenyl)quinoxaline (5021-46-5)

Guidance literature:

With (1-butyl-1-methylpyrrolidinium)trifluoromethanesulfonate; at 80 ℃; for 0.25h;

DOI:10.1080/10426507.2010.538557

Reference yield: 96.0%

1,2-diamino-benzene (95-54-5) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 2-(4-methoxyphenyl)quinoxaline (5021-46-5)

Guidance literature:

With cetyltrimethylammonim bromide; In water; for 8h; Reflux;

DOI:10.3184/030823409X12591655855261

Reference yield: 93.0%

1,2-diamino-benzene (95-54-5) + 4-methoxyphenylacetylen (768-60-5) → 2-(4-methoxyphenyl)quinoxaline (5021-46-5)

Guidance literature:

4-methoxyphenylacetylen; With N-Bromosuccinimide; In acetic acid; for 2h; Inert atmosphere; Reflux;

1,2-diamino-benzene; In acetic acid; at 120 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0035-1561472

upstream raw materials:

2-(4-hydroxyphenyl)quinoxaline

dimethyl sulfate

dimethyl sulfoxide

(4-methoxyphenyl)(quinoxalin-2-yl)methanone

Downstream raw materials:

2-(2-fluoro-4-methoxyphenyl)quinoxaline

2-(2-fluorophenyl)quinoxaline

2-(dimethoxymethyl)-3-(4-methoxyphenyl)quinoxaline

2-(4-methoxyphenyl)-3-phenylquinoxaline