lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

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Chemical Name:lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid
CAS No.:1206909-98-9
Molecular Formula:C₂₈H₂₂Cl₃N₄O₃S*Li
Molecular Weight:607.874
Hs Code.:

lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

Synonyms:lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

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Chemical Property of lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

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Technology Process of lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

There total 5 articles about lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206910-03-3
ethyl 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-[(1R,5S,6s)-6-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-azabicyclo[3.1.0]hex-3-yl]-1,3-thiazole-5-carboxylate

: 1206909-98-9
lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: ethyl 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-[(1R,5S,6s)-6-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-azabicyclo[3.1.0]hex-3-yl]-1,3-thiazole-5-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 110 ℃; for 0.25h; microwave conditions;

With hydrogenchloride; In water; Cooling;

With water; lithium hydroxide;

Reference yield:

: 1206910-00-0
ethyl 2-{(1R,5S,6s)-6-[bis(tert-butoxycarbonyl)amino]-3-azabicyclo[3.1.0]hex-3-yl}-4-(3-bromobenzyl)-1,3-thiazole-5-carboxylate

: 1206909-98-9
lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 0.25 h / 0.12 °C / Microwave irradiation

2: dichloromethane / 0.16 h / 0.25 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.16 h / 0.25 °C

4: lithium hydroxide / tetrahydrofuran; water / 0 h / 0.11 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1206909-98-9
lithium 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-{[(1R,5S,6s)-6-[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl}-1,3-thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / acetonitrile / 0.25 h / 0.12 °C / Microwave irradiation

2: dichloromethane / 0.16 h / 0.25 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.16 h / 0.25 °C

4: lithium hydroxide / tetrahydrofuran; water / 0 h / 0.11 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;