tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate

Base Information

• Chemical Name: tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate
• CAS No.: 67566-88-5
• Molecular Formula: C₂₄H₃₀O₅
• Molecular Weight: 398.499
• Mol file: 67566-88-5.mol

Synonyms:tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate

Chemical Property of tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate

There total 2 articles about tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1,4-di(4-methoxyphenyl)ethanone (120-44-5) + tert-butyl 4-iodobutanoate (6182-78-1) → tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate (67566-88-5)

Guidance literature:

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide; for 0.333333h;

DOI:10.1021/jm00127a022

Reference yield:

2-chloroethylacetic acid tert-butyl ester (3153-32-0) → tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate (67566-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / sodium iodide, sodium hydrogen carbonate, tetrabutylammonium iodide / H₂O / 72 h / 70 °C

2: 89 percent / sodium hydride / diethyl ether; dimethylformamide / 0.33 h

With tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; sodium iodide; In diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00127a022

Reference yield:

tert-butyl 5,6-bis(4-methoxyphenyl)-6-oxohexanoate (67566-88-5) → 5,6-bis(4-methoxyphenyl)-5-octenoic acid (67566-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: TsOH

With toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1002/jlac.197819780506

upstream raw materials:

1,4-di(4-methoxyphenyl)ethanone

tert-butyl 4-iodobutanoate

2-chloroethylacetic acid tert-butyl ester

Downstream raw materials:

5,6-bis(4-methoxyphenyl)-5-octenoic acid

5,6-bis(4-hydroxyphenyl)-5-octenoic acid