tert-butyl 4-chlorobutanoate

Base Information

• Chemical Name: tert-butyl 4-chlorobutanoate
• CAS No.: 3153-32-0
• Molecular Formula: C8H15 Cl O2
• Molecular Weight: 178.659
• Mol file: 3153-32-0.mol

Synonyms:Butyricacid, 4-chloro-, tert-butyl ester (7CI,8CI); 1,1-Dimethylethyl4-chlorobutanoate; tert-Butyl 4-chlorobutanoate; tert-Butyl 4-chlorobutyrate; g-Chlorobutyric acid tert-butylester

Chemical Property of tert-butyl 4-chlorobutanoate

Chemical Property:

• Vapor Pressure: 0.243mmHg at 25°C
• Boiling Point: 206°Cat760mmHg
• Flash Point: 81.2°C
• Density: 1.017g/cm³

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-chlorobutanoate

There total 4 articles about tert-butyl 4-chlorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Chlorobutanoyl chloride (4635-59-0) + tert-butyl alcohol (75-65-0) → 2-chloroethylacetic acid tert-butyl ester (3153-32-0)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

Reference yield: 73.0%

4-Chlorobutanoyl chloride (4635-59-0) → 2-chloroethylacetic acid tert-butyl ester (3153-32-0)

Guidance literature:

With pyridine; dmap; In tert-butyl alcohol;

Reference yield:

γ-chlorobutyric acid (627-00-9) + isobutene (115-11-7,15220-85-6) → 2-chloroethylacetic acid tert-butyl ester (3153-32-0)

Guidance literature:

With sulfuric acid; In diethyl ether;

DOI:10.1021/jm00227a021

upstream raw materials:

γ-chlorobutyric acid

isobutene

4-Chlorobutanoyl chloride

tert-butyl alcohol

Downstream raw materials:

3-[(tert-Butyl)oxycarbonyl]propyl phenylmethyl butane-1,4-dioate

4,4'-bis[3-(tert-butyloxycarbonyl)propoxy]benzophenone

C₁₅H₂₁ClO₃

Refernces

• 1、 Wang, Chun,Wang, Fang,Chen, Xiaoxue,Zou, Yefang,Zhu, Hong,Zhao, Qingjie,Shen, Jingshan,Li, Yan,Li, Yongjun,He, Bin. "The mimics of Nε-acyl-lysine derived from cysteine as sirtuin inhibitors". supporting information. p. 2375 - 2378. Retrieved 2018/06/20.
• 2、 Tran, Joe A.,Chen, Caroline W.,Tucci, Fabio C.,Jiang, Wanlong,Fleck, Beth A.,Chen, Chen. "Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands". . p. 1124 - 1130. Retrieved 2008/09/18.