(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

Base Information

Chemical Name:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate
CAS No.:1279724-22-9
Molecular Formula:C₃₆H₅₈N₈O₂
Molecular Weight:634.909
Hs Code.:

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

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Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

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Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

There total 8 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1279724-21-8
tert-butyl 2-amino-4-(7-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)heptyl)-1H-imidazole-1-carboxylate

: 1279724-22-9
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h;
DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

: 217180-77-3
8-azidooctanoyl chloride

: 1279724-22-9
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 1 h / 0 °C

2: N,N-dimethyl-formamide / 48 h

3: copper(II) sulfate; sodium L-ascorbate / ethanol; dichloromethane; water / 20 °C

4: trifluoroacetic acid / dichloromethane / 16 h

With copper(II) sulfate; sodium L-ascorbate; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

: 1248569-13-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2-(pyridin-2-yl)ethylcarbamate

: 1279724-22-9
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(7-(2-amino-1H-imidazol-4-yl)heptyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: copper(II) sulfate; sodium L-ascorbate / ethanol; dichloromethane; water / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16 h

With sodium hydride; copper(II) sulfate; sodium L-ascorbate; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2010.12.057