2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Base Information

Chemical Name:2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile
CAS No.:1414805-26-7
Molecular Formula:C₁₈H₂₃N₇O
Molecular Weight:353.427
Hs Code.:

Synonyms:2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Suppliers and Price of 2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

There total 8 articles about 2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1414805-25-6
2-((1r,4r)-4-(2-(2-methoxypyridin-3-ylamino)-5-nitropyrimidin-4-ylamino)cyclohexyl)acetonitrile

: 1414805-26-7
2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃;
DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 96.0%

: 1414805-26-7
2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Guidance literature:

Reference yield:

: 20265-38-7
3-amino-2-methoxypyridine

: 1414805-26-7
2-((1r,4r)-4-(5-amino-2-(2-methoxypyridin-3-ylamino)pyrimidin-4-ylamino)cyclohexyl)acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol;
DOI:10.1021/acs.jmedchem.9b00533