1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

Base Information

Chemical Name:1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid
CAS No.:1298041-23-2
Molecular Formula:C₂₅H₃₀FNO₅
Molecular Weight:443.515
Hs Code.:

Synonyms:1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

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Chemical Property of 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

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Technology Process of 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

There total 6 articles about 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1298046-04-4
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

: 1298041-23-2
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

Guidance literature:: 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester; With water; lithium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; water; Inert atmosphere;

Reference yield:

: 6702-50-7
3-hydroxy-4-methoxybenzoate

: 1298041-23-2
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: water; lithium hydroxide / 1,4-dioxane / 0.33 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / 0.33 h / 60 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane; ethyl acetate / 0.05 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / 1,4-dioxane / 0.5 h / 60 °C / Inert atmosphere

5.2: Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 1000572-02-0
2-(2-fluoro-5-methyl-phenyl)-ethanol

: 1298041-23-2
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: water; lithium hydroxide / 1,4-dioxane / 0.33 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / 0.33 h / 60 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane; ethyl acetate / 0.05 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / 1,4-dioxane / 0.5 h / 60 °C / Inert atmosphere

5.2: Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;