1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester
CAS No.:1298046-04-4
Molecular Formula:C₂₆H₃₂FNO₅
Molecular Weight:457.542
Hs Code.:

Synonyms:1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

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Chemical Property of 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

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Technology Process of 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

There total 5 articles about 1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₆ClFO₃

: 92398-50-0
methyl 1-amino-cycloheptanecarboxylate hydrochloride

: 1298046-04-4
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; ethyl acetate; at 20 ℃; for 0.05h; Inert atmosphere;

Reference yield:

: 6702-50-7
3-hydroxy-4-methoxybenzoate

: 1298046-04-4
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: water; lithium hydroxide / 1,4-dioxane / 0.33 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / 0.33 h / 60 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane; ethyl acetate / 0.05 h / 20 °C / Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 1000572-02-0
2-(2-fluoro-5-methyl-phenyl)-ethanol

: 1298046-04-4
1-{3-[2-(2-fluoro-5-methyl-phenyl)-ethoxy]-4-methoxy-benzoylamino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

2.1: water; lithium hydroxide / 1,4-dioxane / 0.33 h / 60 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: thionyl chloride / 0.33 h / 60 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / dichloromethane; ethyl acetate / 0.05 h / 20 °C / Inert atmosphere

With thionyl chloride; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;