N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Base Information

Chemical Name:N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide
CAS No.:468761-81-1
Molecular Formula:C₂₈H₃₁NO₅
Molecular Weight:461.558
Hs Code.:

Synonyms:N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

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Chemical Property of N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

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Technology Process of N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

There total 4 articles about N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-{(2,4-dimethoxybenzyl)-[3-(4-methoxyphenyl)-acryloyl]amino}-3-phenyl-propionic acid methyl ester

: 468761-81-1
N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/jo060148m

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 468761-81-1
N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: 95 percent / HOBt; EDCI / dimethylformamide; CH₂Cl₂ / 12 h

3: 86 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 6 h / 20 °C

With lithium tri(t-butoxy)aluminum hydride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo060148m

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 468761-81-1
N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: 95 percent / HOBt; EDCI / dimethylformamide; CH₂Cl₂ / 12 h

3: 86 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 6 h / 20 °C

With lithium tri(t-butoxy)aluminum hydride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo060148m