N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Base Information

Chemical Name:N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide
CAS No.:468761-51-5
Molecular Formula:C₂₈H₂₉NO₅
Molecular Weight:459.542
Hs Code.:

Synonyms:N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

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Chemical Property of N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

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Technology Process of N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

There total 5 articles about N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 468761-81-1
N-(1-benzyl-2-hydroxyethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

: 468761-51-5
N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jo060148m

Reference yield:

: 2-{(2,4-dimethoxybenzyl)-[3-(4-methoxyphenyl)-acryloyl]amino}-3-phenyl-propionic acid methyl ester

: 468761-51-5
N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 6 h / 20 °C

2: 82 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; lithium tri(t-butoxy)aluminum hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1021/jo060148m

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 468761-51-5
N-(1-benzyl-2-oxoethyl)-N-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / triethylamine; sodium triacetoxyborohydride / 1,2-dichloro-ethane / 24 h / 20 °C

2: 95 percent / HOBt; EDCI / dimethylformamide; CH₂Cl₂ / 12 h

3: 86 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 6 h / 20 °C

4: 82 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; lithium tri(t-butoxy)aluminum hydride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 4: Swern oxidation;
DOI:10.1021/jo060148m