Technology Process of (R)-methyl 3-(benzyloxy)-6-cyano-5-oxohexanoate
There total 7 articles about (R)-methyl 3-(benzyloxy)-6-cyano-5-oxohexanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water;
In
dimethyl sulfoxide;
at 130 ℃;
for 0.75h;
Inert atmosphere;
DOI:10.1021/jo402829b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluorormethanesulfonic acid / cyclohexane; dichloromethane / 24 h / 0 °C
2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 48 h / 20 °C
3.1: acetyl chloride / dichloromethane / 12 h / 0 - 20 °C
4.1: C44H45F6N3O5S / tert-butyl methyl ether / 168 h / 20 °C / Inert atmosphere
5.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
5.2: 24 h / 20 °C / Inert atmosphere
6.1: water / dimethyl sulfoxide / 0.75 h / 130 °C / Inert atmosphere
With
lithium hydroxide monohydrate; trifluorormethanesulfonic acid; C44H45F6N3O5S; water; triethylamine; acetyl chloride;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; cyclohexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo402829b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trifluorormethanesulfonic acid / cyclohexane; dichloromethane / 24 h / 0 °C
2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 48 h / 20 °C
3.1: acetyl chloride / dichloromethane / 12 h / 0 - 20 °C
4.1: C44H45F6N3O5S / tert-butyl methyl ether / 168 h / 20 °C / Inert atmosphere
5.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
5.2: 24 h / 20 °C / Inert atmosphere
6.1: water / dimethyl sulfoxide / 0.75 h / 130 °C / Inert atmosphere
With
lithium hydroxide monohydrate; trifluorormethanesulfonic acid; C44H45F6N3O5S; water; triethylamine; acetyl chloride;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; cyclohexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo402829b
