Technology Process of methyl 2-((4R,6S)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
There total 8 articles about methyl 2-((4R,6S)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
acetone;
at 20 ℃;
for 6h;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo402829b
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: trifluorormethanesulfonic acid / cyclohexane; dichloromethane / 24 h / 0 °C
2.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 48 h / 20 °C
3.1: acetyl chloride / dichloromethane / 12 h / 0 - 20 °C
4.1: C44H45F6N3O5S / tert-butyl methyl ether / 168 h / 20 °C / Inert atmosphere
5.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
5.2: 24 h / 20 °C / Inert atmosphere
6.1: water / dimethyl sulfoxide / 0.75 h / 130 °C / Inert atmosphere
7.1: iron(III) chloride / dichloromethane / 48 h / 0 - 5 °C / Inert atmosphere
8.1: diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 - -10 °C / Inert atmosphere
8.2: 6 h / -78 °C / Inert atmosphere
9.1: toluene-4-sulfonic acid / acetone / 6 h / 20 °C / Inert atmosphere
With
iron(III) chloride; lithium hydroxide monohydrate; trifluorormethanesulfonic acid; diethyl methoxy borane; C44H45F6N3O5S; water; toluene-4-sulfonic acid; triethylamine; acetyl chloride;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; cyclohexane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo402829b
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 48 h / 20 °C
2.1: acetyl chloride / dichloromethane / 12 h / 0 - 20 °C
3.1: C44H45F6N3O5S / tert-butyl methyl ether / 168 h / 20 °C / Inert atmosphere
4.1: triethylamine / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
4.2: 24 h / 20 °C / Inert atmosphere
5.1: water / dimethyl sulfoxide / 0.75 h / 130 °C / Inert atmosphere
6.1: iron(III) chloride / dichloromethane / 48 h / 0 - 5 °C / Inert atmosphere
7.1: diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 - -10 °C / Inert atmosphere
7.2: 6 h / -78 °C / Inert atmosphere
8.1: toluene-4-sulfonic acid / acetone / 6 h / 20 °C / Inert atmosphere
With
iron(III) chloride; lithium hydroxide monohydrate; diethyl methoxy borane; C44H45F6N3O5S; water; toluene-4-sulfonic acid; triethylamine; acetyl chloride;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo402829b
