3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Base Information

Chemical Name:3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide
CAS No.:1286232-19-6
Molecular Formula:C₂₄H₂₈ClN₅O₂
Molecular Weight:453.972
Hs Code.:

Synonyms:3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

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Chemical Property of 3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

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Technology Process of 3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

There total 6 articles about 3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 768-08-1
2-(2-methylpiperidin-1-yl)ethanamine

: 950525-42-5
4-[3-(3-chloro-5-methoxyphenyl)-1H-pyrazol-4-yl]pyridine

: 1885-14-9
phenyl chloroformate

: 1286232-19-6
3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

: C₂₄H₂₈ClN₅O₂

Guidance literature:: 4-[3-(3-chloro-5-methoxyphenyl)-1H-pyrazol-4-yl]pyridine; phenyl chloroformate; With triethylamine; In tetrahydrofuran; at 0 ℃;

2-(2-methylpiperidin-1-yl)ethanamine; With potassium carbonate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/ardp.201000057

Reference yield:

: C₁₇H₁₇ClN₂O₂

: 1286232-19-6
3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 20 °C

2.1: triethylamine / tetrahydrofuran / 0 °C

2.2: 1 h / 20 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1002/ardp.201000057

Reference yield:

: 51-36-5
3,5-dichlorobenzoic acid

: 1286232-19-6
3-(3-chloro-5-methoxyphenyl)-N-(2-(2-methylpiperidin-1-yl)ethyl)-4-(pyridin-4-yl)-1H-pyrazole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium methylate / 15 h / Heating

2.1: acetyl chloride / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -25 - 20 °C

4.1: 18 h / 20 °C

5.1: hydrazine hydrate / ethanol / 20 °C

6.1: triethylamine / tetrahydrofuran / 0 °C

6.2: 1 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium methylate; hydrazine hydrate; triethylamine; acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1002/ardp.201000057