C₄₂H₄₇N₄O₁₃P

Base Information

• Chemical Name: C₄₂H₄₇N₄O₁₃P
• CAS No.: 75715-12-7
• Molecular Formula: C₄₂H₄₇N₄O₁₃P
• Molecular Weight: 846.828
• Mol file: 75715-12-7.mol

Synonyms:C₄₂H₄₇N₄O₁₃P

Chemical Property of C₄₂H₄₇N₄O₁₃P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₄₇N₄O₁₃P

There total 10 articles about C₄₂H₄₇N₄O₁₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate (195307-35-8) → C42H47N4O13P (75715-12-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

Reference yield: 75.0%

C48H61N4O13PSi → C42H47N4O13P (75715-12-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1021/jacs.9b13898

Reference yield: 60.0%

C53H65N4O15P (108311-25-7) → C42H47N4O13P (75715-12-7)

Guidance literature:

With sodium hydroxide; In pyridine; methanol; at 4 ℃; in 20 to 40 min;

DOI:10.1016/S0040-4039(00)85202-8

upstream raw materials:

C₅₃H₆₅N₄O₁₅P

(Sp)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidylyl-(3'->5')-3'-O-[(1,1-dimethylethyl)diphenylsilyl]-2'-deoxythymidine 3'-methylphosphonate

1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

5'-O-(4-4'-dimethoxytrityl)thymidine

Refernces

• 1、 Schweitzer, Markus,Engels, Joachim W.. "Methylphosphonate modified hairpin loops". . p. 317 - 326. Retrieved 2007/10/03.