195307-35-8Relevant academic research and scientific papers
Triarylmethyl substituted 4,5-dicyanoimidazoles as activators for Rp- diastereoselective synthesis of TpN dinucleoside methylphosphonates
Schell, Peter,Laux, Wolfgang H. G.,Engels, Joachim W.
, p. 1169 - 1174 (1999)
2-Triarylmethyl-4,5-dicyanoimidazoles 1-3 were synthesized and tested as activators in the methylphosphonamidite approach. TpN dinucleoside methylphosphonates generated showed diastereoselectivity of up to 8/1 (Rp/Sp). The influence of the different triarylmethyl substituents on diastereoselectivity is shown.
Rp-Diastereoselective synthesis of dinucleoside methylphosphonates by the phosphoramidite approach
Schell, Peter,Engels, Joachim W.
, p. 8629 - 8632 (1998)
In order to obtain diastereomeric control in the azole catalyzed coupling reaction of methylphosphonamidites, 2-(2',4',6'-trimethylbiphenyl- 2-yl)-4,5-dicyanoimidazole 2 was synthesized. With its use as activator Rp- diastereoselective synthesis of dinucleoside methylphosphonates could be achieved for the first time by the phosphoramidite approach. Selectivities were up to 84 / 16 (Rp / Sp). The mechanism of the reaction is based on dynamic kinetic resolution.
Methylphosphonate modified hairpin loops
Schweitzer, Markus,Engels, Joachim W.
, p. 317 - 326 (2007/10/03)
We synthesized and analyzed DNA hairpin molecules with methylphosphonate linkages of defined stereochemistry in the loop region. Dinucleotide building blocks ApA and TpT (p indicating methylphosphonate linkage with either Rp or Sp configuration) were synt
5-[2-(2-Methoxy)bornyl]tetrazole as catalyst for dlastereoselective synthesis of 2′-deoxydlnucleoside (3′, 5′)-methylphosphonates
Schell, Peter,Engels, Joachim W.
, p. 769 - 772 (2007/10/03)
The synthesis of 5-[2-(2-methoxy)bornyl]tetrazole 1 is described. 1 is used as catalyst for the diastereoselective synthesis of some 2′-deoxy dinucleoside (3′, 5′)methylphosphonates in solution. Copyright 1997 by Marcel Dekker, Inc.
