6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

Base Information

• Chemical Name: 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline
• CAS No.: 103046-35-1
• Molecular Formula: C₂₅H₂₅NO₃
• Molecular Weight: 387.478
• Mol file: 103046-35-1.mol

Synonyms:6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

Chemical Property of 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline

There total 12 articles about 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) (31804-69-0) → 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline (103046-35-1)

Guidance literature:

With trichlorophosphate; In dichloromethane; for 3h; Heating;

DOI:10.1021/np980008a

Reference yield:

3-benzyloxy-4-methoxyphenylethylamine (36455-21-7) → 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline (103046-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 89 percent / POCl₃ / CH₂Cl₂ / 3 h / Heating

With sodium hydroxide; trichlorophosphate; In dichloromethane;

DOI:10.1021/np980008a

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → 6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline (103046-35-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / NH₄OAc/AcOH / 3 h / Heating

2: 68 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

3: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

4: 89 percent / POCl₃ / CH₂Cl₂ / 3 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; acetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/np980008a

upstream raw materials:

(4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)

isovanillin

(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

3-benzyloxy-4-methoxyphenylethylamine

Downstream raw materials:

(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline