(4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)

Base Information

• Chemical Name: (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)
• CAS No.: 31804-69-0
• Molecular Formula: C₂₅H₂₇NO₄
• Molecular Weight: 405.494
• Mol file: 31804-69-0.mol

Synonyms:(4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)

Chemical Property of (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide)

There total 10 articles about (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-benzyloxy-4-methoxyphenylethylamine (36455-21-7) + 4-methoxyphenyl-acetic chloride (4693-91-8) → (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) (31804-69-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/np980008a

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) (31804-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / NH₄OAc/AcOH / 3 h / Heating

2: 68 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

3: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; acetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/np980008a

Reference yield:

isovanillin (621-59-0) → (4-methoxy-phenyl)-acetic acid-(3-benzyloxy-4-methoxy-phenethylamide) (31804-69-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / ethanol / 5 h / Heating

2: 77 percent / NH₄OAc/AcOH / 3 h / Heating

3: 68 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / Heating

4: 44 percent / NaOH / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; ammonium acetate; potassium carbonate; acetic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;

DOI:10.1021/np980008a

upstream raw materials:

3-benzyloxy-4-methoxyphenylethylamine

4-methoxyphenyl-acetic chloride

isovanillin

(E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene

Downstream raw materials:

(S)-6-Benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline

6-benzyloxy-7-methoxy-1-(4-methoxy-benzyl)-3,4-dihydro-isoquinoline