N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

Base Information

Chemical Name:N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester
CAS No.:1380665-37-1
Molecular Formula:C₂₇H₃₃FN₆O₇
Molecular Weight:572.593
Hs Code.:

N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

Synonyms:N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

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Chemical Property of N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

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Technology Process of N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

There total 7 articles about N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 67-56-1
methanol

: 1380665-35-9
N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-isocyanato-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

: 1380665-37-1
N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

Guidance literature:: With silica gel;

Reference yield:

: 1380665-18-8
N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

: 1380665-37-1
N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

7: dichloromethane / 1 h / Inert atmosphere; Reflux

8: silica gel

With 4-methyl-morpholine; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; hydrogen; silica gel; sodium carbonate; Dess-Martin periodane; triethylamine; HATU; palladium 10% on activated carbon; In methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1380665-22-4
N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-7-formyl-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N',N'-dimethyl-ethanediamide

: 1380665-37-1
N-[10-[[2-(dimethylamino)-1,2-dioxoethyl]amino]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-4,8,9,10-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-7(6H)-yl]-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

2: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

3: dichloromethane / 1 h / Inert atmosphere; Reflux

4: silica gel

With sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; silica gel; triethylamine; In dichloromethane; water; tert-butyl alcohol;