Technology Process of phenylmethyl [6-(4-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]carbamate
There total 7 articles about phenylmethyl [6-(4-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C23H20FN5O2; acetyl chloride;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
for 0.5h;
Reflux;
With
sodium hydrogencarbonate;
In
chloroform;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere
2.1: ammonia / methanol / 1 h / 20 °C / Inert atmosphere
3.1: ammonium acetate; acetic acid / 24 h / 20 °C
4.1: Lawessons reagent / toluene / 4 h / Inert atmosphere; Reflux
5.1: hydrazine hydrate / methanol / 2 h / 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
6.2: 0.5 h / Reflux
With
Lawessons reagent; dmap; ammonium acetate; ammonia; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere
2.1: ammonia / methanol / 1 h / 20 °C / Inert atmosphere
3.1: ammonium acetate; acetic acid / 24 h / 20 °C
4.1: Lawessons reagent / toluene / 4 h / Inert atmosphere; Reflux
5.1: hydrazine hydrate / methanol / 2 h / 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
6.2: 0.5 h / Reflux
With
Lawessons reagent; dmap; ammonium acetate; ammonia; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
