4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide
CAS No.:1355631-28-5
Molecular Formula:C₁₆H₁₁ClF₅NO₄S
Molecular Weight:443.779
Hs Code.:

Synonyms:4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

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Chemical Property of 4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

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Technology Process of 4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

There total 4 articles about 4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1355070-71-1
4-(Bromomethyl)-2,5-difluoro-N-(methylsulfonyl)benzamide

: 37900-81-5
2-chloro-4-hydroxybenzotrifluoride

: 1355631-28-5
4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: 4-(Bromomethyl)-2,5-difluoro-N-(methylsulfonyl)benzamide; 3-chloro-4-(trifluoromethyl)phenol; With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 16h;

With hydrogenchloride; In water; dimethyl sulfoxide;

Reference yield:

: 94444-58-3
2-chloro-4-fluoro-1-(trifluoromethyl)benzene

: 1355631-28-5
4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2-(Trimethylsilyl)ethanol; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 h / 0 °C

2: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With 2-(Trimethylsilyl)ethanol; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 1355631-28-5
4-{[3-chloro-4-(trifluoromethyl)phenoxy]methyl}-2,5-difluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 4 h / Inert atmosphere; Reflux

3: potassium carbonate / dimethyl sulfoxide / 16 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane;