Technology Process of C26H35FN10O2
There total 17 articles about C26H35FN10O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(5-amino-2-cyclopropyl-4-fluorophenyl)-4-methyl-1H-tetrazol-5(4H)-one; 5-aminocarbonyl-2-chloro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride;
With
toluene-4-sulfonic acid;
In
isopropyl alcohol;
at 100 ℃;
Sealed vial;
With
sodium hydroxide;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: nitric acid; sulfuric acid / 1.08 h / -20 - -15 °C
2: toluene / 2.5 h / 80 °C / Inert atmosphere
3: trimethylsilylazide / 80 °C / Inert atmosphere
4: potassium carbonate / N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere
5: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere
6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 80 °C
7: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C / Sealed vial
With
hydrogenchloride; tin(II) chloride dihdyrate; trimethylsilylazide; sulfuric acid; nitric acid; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid;
palladium diacetate; tricyclohexylphosphine;
In
ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
5: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 2.5 h / 80 °C / Inert atmosphere
2: trimethylsilylazide / 80 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere
4: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere
5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 80 °C
6: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C / Sealed vial
With
hydrogenchloride; tin(II) chloride dihdyrate; trimethylsilylazide; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid;
palladium diacetate; tricyclohexylphosphine;
In
ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
4: Suzuki Coupling;