(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

Base Information

• Chemical Name: (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester
• CAS No.: 64231-47-6
• Molecular Formula: C₈H₁₄O₅
• Molecular Weight: 190.196
• Mol file: 64231-47-6.mol

Synonyms:(S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

Chemical Property of (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester

There total 4 articles about (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethanol (64-17-5) + L,L-dilactide (4511-42-6,26680-10-4,26969-66-4,615-95-2) → (S)-Ethyl lactate (687-47-8) + (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester (64231-47-6)

Guidance literature:

With [Mg(tbpca)2]; In dichloromethane; at 25 ℃; for 72h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c1dt10087d

Reference yield:

ethanol (64-17-5) + D-lactide (13076-17-0,26680-10-4,26969-66-4,615-95-2) → (S)-Ethyl lactate (687-47-8) + (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester (64231-47-6)

Guidance literature:

With dibutylmagnesium; In hexane; dichloromethane; at 20 ℃; for 0.0166667h; Time; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1016/j.tetlet.2014.07.103

Reference yield:

ethanol (64-17-5) + 3,6-dimethyl-1,4-dioxane-2,5-dione (26680-10-4,26969-66-4,615-95-2) → (R)-Ethyl lactate (7699-00-5) + (S)-2-hydroxy-propionic acid (S)- 1-ethoxycarbonyl-ethyl ester (64231-47-6)

Guidance literature:

With Candida antarctica lipase B; In tetrahydrofuran; hexane; at 60 ℃; for 66h;

DOI:10.1016/j.tetlet.2006.07.034

upstream raw materials:

ethanol

3,6-dimethyl-1,4-dioxane-2,5-dione

L,L-dilactide

D-lactide

Downstream raw materials:

L-Lactic acid