8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

Base Information

• Chemical Name: 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid
• CAS No.: 149873-69-8
• Molecular Formula: C₂₂H₁₉ClFN₃O₂
• Molecular Weight: 411.863

Synonyms:8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

Chemical Property of 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid

There total 3 articles about 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester (149873-68-7) → 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid (149873-69-8)

Guidance literature:

With potassium hydroxide; In methanol; water; for 6h; Heating;

DOI:10.1021/jo00064a014

Reference yield:

7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester (77132-89-9) → 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid (149873-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Raney-Ni / tetrahydrofuran; ethanol / 5 h / 760 Torr

2: 97 percent / KOH / methanol; H₂O / 6 h / Heating

With potassium hydroxide; nickel; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1021/jo00064a014

Reference yield:

pivalaldehyde (630-19-3) → 8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid (149873-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Raney-Ni / tetrahydrofuran; ethanol / 5 h / 760 Torr

2: 97 percent / KOH / methanol; H₂O / 6 h / Heating

With potassium hydroxide; nickel; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1021/jo00064a014

upstream raw materials:

8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxylic acid ethyl ester

7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-3H-1,4-benzodiazepine-2-acetic acid ethyl ester

pivalaldehyde

Downstream raw materials:

-8-chloro-1-(1,1-dimethylethyl)-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine

8-chloro-6-(2-fluorophenyl)-5,6-dihydro-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine

-(+)-8-chloro-6-(2-fluorophenyl)-1-(1,1-dimethylethyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

8-chloro-1-(1,1-dimethylethyl)-5,6-dihydro-6-(2-fluorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

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