(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

Base Information

Chemical Name:(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one
CAS No.:1333115-61-9
Molecular Formula:C₂₀H₂₁F₃N₂O₄S
Molecular Weight:442.459
Hs Code.:

Synonyms:(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

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Chemical Property of (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

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Technology Process of (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

There total 11 articles about (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1333115-60-8
(S)-2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

: 1333115-61-9
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1333115-61-9
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

7.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

8.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane

10.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 1333115-61-9
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: hydrogenchloride / 4 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane; water / 3 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

3.2: 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol

6.1: triethylamine / dichloromethane / 12 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

8.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

9.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

10.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

11.1: trifluoroacetic acid / dichloromethane

12.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;