(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

Base Information

Chemical Name:(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione
CAS No.:1333115-62-0
Molecular Formula:C₂₀H₂₁F₃N₂O₃S₂
Molecular Weight:458.526
Hs Code.:

Synonyms:(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

Chemical Property:

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Technology Process of (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

There total 10 articles about (S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1333115-61-9
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-one

: 1333115-62-0
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

Guidance literature:: With Lawessons reagent; In toluene; at 80 ℃; for 0.5h;

Reference yield:

: 77119-85-8
N-(tert-butoxycarbonyl)-D-phenylalaninal

: 1333115-62-0
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

Guidance literature:: Multi-step reaction with 10 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol

3: triethylamine / dichloromethane / 12 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

6: triethylamine / dmap / dichloromethane / 12 h / 20 °C

7: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

8: trifluoroacetic acid / dichloromethane

9: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

10: Lawessons reagent / toluene / 0.5 h / 80 °C

With Lawessons reagent; hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1333115-62-0
(S)-5-benzyl-4-((2-(trifluoromethoxy)phenyl)sulfonyl)-1,4-diazocan-2-thione

Guidance literature:: Multi-step reaction with 11 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

7.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

8.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane

10.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

11.1: Lawessons reagent / toluene / 0.5 h / 80 °C

With Lawessons reagent; hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;