N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

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Chemical Name:N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine
CAS No.:1421373-18-3
Molecular Formula:C₁₈H₁₃FN₆O₃
Molecular Weight:380.338
Hs Code.:

Synonyms:N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

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Chemical Property of N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

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Technology Process of N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

There total 3 articles about N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 4-(pyrazole[1,5-a]pyridin-3-yl)-2-chloropyrimidine

: 1075705-01-9
4-fluoro-2-methoxy-5-nitro-phenylamine

: 1421373-18-3
N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

Guidance literature:: With toluene-4-sulfonic acid; at 125 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm400822z

Reference yield:

: 1434180-02-5
(E)-2-chloro-4-(2-ethoxyvinyl)pyrimidine

: 1421373-18-3
N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 25 - 110 °C

2: toluene-4-sulfonic acid / 22 h / 125 °C

With potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;

Reference yield:

: 450-91-9
4-fluoro-2-methoxyaniline

: 1421373-18-3
N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; potassium nitrate / 15 °C / Cooling with ice

2: toluene-4-sulfonic acid / 22 h / 125 °C

With sulfuric acid; toluene-4-sulfonic acid; potassium nitrate;