4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

Base Information

Chemical Name:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)
CAS No.:130475-33-1
Molecular Formula:C₂₄H₂₉N₅O₄S
Molecular Weight:483.591
Hs Code.:

Synonyms:4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

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Chemical Property of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

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Technology Process of 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

There total 6 articles about 4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 593-56-6
N-methoxylamine hydrochloride

: 130475-22-8
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione

: 130475-33-1
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

Guidance literature:: With sodium acetate; In ethanol; Heating;

Reference yield:

: 39978-14-8
methyl 3-amino-4-thiophenecarboxylate hydrochloride

: 130475-33-1
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

4: 70 percent / 50percent aq. NaOH / methanol / Heating

5: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

6: 85 percent / NaOAc / ethanol / Heating

With sodium hydroxide; methanesulfonic acid; trimethylaluminum; sodium acetate; phosphorus pentoxide; sodium hydride; In methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 118252-16-7
ethyl (4-methoxycarbonyl)thiophene-3-carbamate

: 130475-33-1
4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-7,8-dihydro-6H-1-thia-4,5a-diaza-benzo[cd]azulene-3,5,9-trione 9-(O-methyl-oxime)

Guidance literature:: Multi-step reaction with 5 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 1.) NaH / 1.) DMF, 30 min, r.t., 2.) 16 h, r.t.

3: 70 percent / 50percent aq. NaOH / methanol / Heating

4: 70 percent / P₂O₅, CH₃SO₃H (1:10) / Ambient temperature

5: 85 percent / NaOAc / ethanol / Heating

With sodium hydroxide; methanesulfonic acid; trimethylaluminum; sodium acetate; phosphorus pentoxide; sodium hydride; In methanol; ethanol; toluene;