1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine

Base Information

• Chemical Name: 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine
• CAS No.: 116708-12-4
• Molecular Formula: C₂₃H₂₆N₂O
• Molecular Weight: 346.472

Synonyms:1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine

Chemical Property of 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine

Chemical Property:

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Technology Process of 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine

There total 1 articles about 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzyl-3,4-dimethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile (116708-14-6) + p-methoxybenzyl chloride (824-94-2) → 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine (116708-12-4)

Guidance literature:

Yield given;

DOI:10.1016/S0040-4039(00)61840-3

Reference yield: 73.0%

4-methoxybenzylmagnesium chloride (38769-92-5) + 1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine (116708-12-4) → 2-benzyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine (143950-94-1)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/0223-5234(92)90150-Y

Reference yield: 46.0%

1-benzyl-2-cyano-3,4-dimethyl-2-(p-methoxybenzyl)-1,2,5,6-tetrahydropyridine (116708-12-4) + phenylmagnesium bromide (100-58-3) → 1-benzyl-2-phenyl-2-(p-methoxybenzyl)-3,4-dimethyl-1,2,5,6-tetrahydropyridine (116708-04-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/0223-5234(92)90150-Y

upstream raw materials:

1-Benzyl-3,4-dimethyl-1,2,5,6-tetrahydro-pyridine-2-carbonitrile

p-methoxybenzyl chloride

Downstream raw materials:

1-benzyl-2-phenyl-2-(p-methoxybenzyl)-3,4-dimethyl-1,2,5,6-tetrahydropyridine

2-benzyl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6-tetrahydropyridine

4-((2R,6S,11S)-3,6,11-Trimethyl-3,4,5,6-tetrahydro-1H-2,6-methano-benzo[d]azocin-2-ylmethyl)-phenol

2-phenyl-6,11α-dimethyl-8-hydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine

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