ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

Base Information

Chemical Name:ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate
CAS No.:1489004-24-1
Molecular Formula:C₁₉H₂₆ClNO₄
Molecular Weight:367.873
Hs Code.:

Synonyms:ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

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Chemical Property of ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

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Technology Process of ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

There total 4 articles about ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 24424-99-5
di-tert-butyl dicarbonate

: ethyl 2-(4-chlorophenyl)-3-(isopropylamino)acrylate

: 1489004-24-1
ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

Guidance literature:: With dmap; tributyl-amine; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 5.5h; Reagent/catalyst; Temperature; Large scale;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₄H₁₈ClNO₂

: 1489004-24-1
ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 30h; Large scale;

Reference yield:

: 14062-24-9
4-chloro-benzeneacetic acid, ethyl ester

: 1489004-24-1
ethyl (E)-3-[(tert-butoxycarbonyl)(isopropyl)amino]-2-(4-chlorophenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tert-butyl methyl ether / 1.5 h / 0 - 10 °C / Large scale

1.2: 0.5 h / 0 - 10 °C / pH 2 / Large scale

2.1: acetic acid / 3 h / 0 - 10 °C / Large scale

3.1: triethylamine; dmap / N,N-dimethyl-formamide / 30 h / 60 - 65 °C / Large scale

With dmap; potassium tert-butylate; acetic acid; triethylamine; In tert-butyl methyl ether; N,N-dimethyl-formamide;