N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

Base Information

• Chemical Name: N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide
• CAS No.: 168543-06-4
• Molecular Formula: C₁₇H₁₆N₂O₃
• Molecular Weight: 296.326
• Mol file: 168543-06-4.mol

Synonyms:N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

Chemical Property of N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

There total 5 articles about N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pyridine-2,3-dicarboxylic anhydride (699-98-9) → N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide (168543-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

3: Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

With aluminium trichloride; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00016a014

Reference yield:

3-(4-methylbenzoyl)-2-pyridine carboxylic acid (116060-91-4) → N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide (168543-06-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

2: Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00016a014

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → N-(formylmethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide (168543-06-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

3: Et₃N / CH₂Cl₂ / 15 h / Ambient temperature

With aluminium trichloride; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00016a014

upstream raw materials:

3-p-toluoyl-pyridine-2-carbonyl chloride

N-(methyl)aminoacetaldehyde dimethyl acetal

Pyridine-2,3-dicarboxylic anhydride

3-(4-methylbenzoyl)-2-pyridine carboxylic acid

Downstream raw materials:

7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-1,7-naphthyridine-6-carboxylic acid

7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarboxaldehyde