tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate

Base Information

• Chemical Name: tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate
• CAS No.: 643094-38-6
• Molecular Formula: C₂₇H₃₉BrClNO₃Si
• Molecular Weight: 569.054

Synonyms:tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate

Chemical Property of tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate

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Technology Process of tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate

There total 2 articles about tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate (643093-71-4) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate (643094-38-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 120h;

DOI:10.1021/jm701324c

Reference yield:

1H-imidazole (288-32-4) + (1R)-2-[[2-(4-Bromophenyl)ethyl]amino]-1-(3-chlorophenyl)ethanol (643093-70-3) + di-tert-butyl dicarbonate (24424-99-5) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate (643094-38-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 63.0%

4-{[tert-butyl(dimethyl)silyl]oxy}-N-methoxy-N-methyl benzamide (643094-45-5) + tert-butyl 2-(4-bromophenyl)ethyl[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-chlorophenyl)ethyl]carbamate (643094-38-6) → tert-butyl 2-[4-(4-{[tert-butyl(dimethyl)silyl]oxy}benzoyl)phenyl]ethyl[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]carbamate

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

DOI:10.1021/jm701324c

upstream raw materials:

1H-imidazole

(1R)-2-[[2-(4-Bromophenyl)ethyl]amino]-1-(3-chlorophenyl)ethanol

di-tert-butyl dicarbonate

tert-butyldimethylsilyl chloride

Downstream raw materials:

tert-butyl N-[2-[4-[4-[[tert-butyl(dimethyl)silyl]oxy]benzoyl]phenyl]ethyl]-N-[(2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-2-(3-chlorophenyl)ethyl]carbamate

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