Acetone hydrazone

Base Information

• Chemical Name: Acetone hydrazone
• CAS No.: 5281-20-9
• Molecular Formula: C3H8 N2
• Molecular Weight: 72.1099
• Hs Code.: 2928000090
• European Community (EC) Number: 226-110-0
• DSSTox Substance ID: DTXSID10967276
• Nikkaji Number: J27.086E
• Mol file: 5281-20-9.mol

Synonyms:AceH;acetone hydrazone

Chemical Property of Acetone hydrazone

Chemical Property:

• Vapor Pressure: 23.6mmHg at 25°C
• Melting Point: 128 °C
• Boiling Point: 110.5°C at 760 mmHg
• PKA: 4.82±0.70(Predicted)
• Flash Point: 20.7°C
• PSA: 38.38000
• Density: 0.9g/cm³
• LogP: 1.04120
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 72.068748264
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

98%Min ^*data from raw suppliers

ACETONE HYDRAZONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NN)C

Technology Process of Acetone hydrazone

There total 11 articles about Acetone hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

acetone (67-64-1) → acetone hydrazone (5281-20-9)

Guidance literature:

With barium(II) oxide; hydrazine; In methanol; at -5 - 20 ℃;

Reference yield:

propan-2-one azine (627-70-3) → acetone hydrazone (5281-20-9)

Guidance literature:

With hydrazine; at 100 ℃;

Reference yield:

1,2-propanediene (463-49-0) → acetone hydrazone (5281-20-9) + allylhydrazine (7422-78-8)

Guidance literature:

With C₂₄H₂₀B^(1-)*C₂₇H₃₉AuClN*K⁽¹⁺⁾; hydrazine; at 130 ℃; for 14h; Inert atmosphere;

DOI:10.1002/anie.201100740

upstream raw materials:

acetone oxime

acetone

propan-2-one azine

Acetone thiosemicarbazone

Downstream raw materials:

hydrazinoisobutyric acid

N-isopropylhydrazine

(±)-trans-ethyl 2,2-dimethyl-3-phenylcyclopropanecarboxylate

N-(2,4-dinitrophenyl)-N'-isopropylidene-hydrazine

Refernces

• 1、 Liang, Qianqian,Liu, Hong-Min,Ma, Li-Ying,Ren, Hongmei,Wu, Yang,Zhang, Kun,Zhang, Xinhui,Zhao, Bing,Zheng, Yi-Chao. "Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)". . . Retrieved 2020/03/10.
• 2、 Peil, Sebastian,Guthertz, Alexandre,Biberger, Tobias,Fürstner, Alois. "Hydrogenative Cyclopropanation and Hydrogenative Metathesis". supporting information. p. 8851 - 8856. Retrieved 2019/05/28.