(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

Base Information

Chemical Name:(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole
CAS No.:213008-26-5
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

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Chemical Property of (3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

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Technology Process of (3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

There total 6 articles about (3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 114715-35-4
(R)-3-methanesulfonyloxy-1-(phenylmethyl)-pyrrolidine

: 213008-03-8
5-methoxy-4-indanol

: 213008-26-5
(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

Guidance literature:: 5-methoxy-4-indanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

(R)-3-methanesulfonyloxy-1-(phenylmethyl)-pyrrolidine; In N,N-dimethyl-formamide; at 70 ℃; for 12h;
DOI:10.1081/SCC-100104420

Reference yield:

: 6342-80-9
4,5-dimethoxyindanone

: 213008-26-5
(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂ / Pd/C / acetic acid / 3 h / 55 °C / 2844.31 Torr

2.1: 57 percent / DL-methionine / various solvent(s) / 3 h / 15 - 20 °C

3.1: sodium hydride / dimethylformamide / 1 h / 0 °C

3.2: 85 percent / dimethylformamide / 12 h / 70 °C

With hydrogen; sodium hydride; DL-methionine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1081/SCC-100104420

Reference yield:

: 7345-82-6
trans-2,3-dimethoxycinnamic acid

: 213008-26-5
(3S)-1-benzyl-3-[(5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy]tetrahydro-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Pd/C / ethyl acetate / 2 h / 45 °C / 2585.74 Torr

2.1: 92 percent / polyphosphoric acid / 1.25 h / 70 °C

3.1: 100 percent / H₂ / Pd/C / acetic acid / 3 h / 55 °C / 2844.31 Torr

4.1: 57 percent / DL-methionine / various solvent(s) / 3 h / 15 - 20 °C

5.1: sodium hydride / dimethylformamide / 1 h / 0 °C

5.2: 85 percent / dimethylformamide / 12 h / 70 °C

With PPA; hydrogen; sodium hydride; DL-methionine; palladium on activated charcoal; In acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1081/SCC-100104420