1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate
CAS No.:1621435-42-4
Molecular Formula:C₂₁H₃₁NO₅
Molecular Weight:377.481
Hs Code.:

Synonyms:1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Suppliers and Price of 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

There total 7 articles about 1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

: 3587-60-8
Benzyloxymethyl chloride

: 1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate

: 1621435-42-4
1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: 1-tert-butyl 2-ethyl 5-methylpyrrolidine-1,2-dicarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;

Benzyloxymethyl chloride; In tetrahydrofuran; at -30 ℃; for 2h;

Reference yield:

: (S)-ethyl 2-((tert-butoxycarbonyl)amino)-5-oxohexanoate

: 1621435-42-4
1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h

3.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

4.2: 2 h / -30 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 100911-28-2
5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester

: 1621435-42-4
1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h

2.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

3.2: 2 h / -30 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water;