1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

Base Information

Chemical Name:1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione
CAS No.:628716-91-6
Molecular Formula:C₁₈H₂₃BrN₂O₅
Molecular Weight:427.295
Hs Code.:

Synonyms:1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

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Technology Process of 1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

There total 1 articles about 1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 310903-92-5
(Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 628716-91-6
1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

Guidance literature:: With hydrogen; Rh on carbon; In methanol; for 1h; under 760 Torr;
DOI:10.1248/cpb.51.821

Reference yield: 76.6%

: 108-24-7
acetic anhydride

: 628716-91-6
1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

: 628716-95-0
1,4-diacetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

Guidance literature:: With pyridine; dmap; at 25 ℃; for 1h;
DOI:10.1248/cpb.51.821

Reference yield:

: 628716-91-6
1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-2,5-piperazinedione

: 6,7,8,9-tetrahydro-9-[(5-isopropoxy-4-methoxy-3-methylphenyl)methyl]-4-methyl-5-(4-methylbenzenesulfoxy)-4-methyl-8-oxo-7-phenylmethyl-10H-1,3-dioxolo-[6,7]indeno[1,2-b]pyrazine-10-carboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 76.6 percent / pyridine; DMAP / 1 h / 25 °C

2.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

4.1: 66.2 percent / K₂CO₃ / methanol / 2 h / 25 °C

5.1: 98.9 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 2 h / 25 °C

6.1: 45.0 mg / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 1 h / 0 °C

7.1: 36.0 mg / TFA / 1 h / 0 °C

8.1: 75.1 percent / H₂ / Pd/C / ethanol / 1 h / 760 Torr

With pyridine; dmap; lithium tri(t-butoxy)aluminum hydride; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821