(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Base Information

Chemical Name:(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione
CAS No.:628717-16-8
Molecular Formula:C₄₁H₄₁BrN₂O₁₀S
Molecular Weight:833.754
Hs Code.:

(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Synonyms:(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

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Chemical Property of (Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

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Technology Process of (Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

There total 7 articles about (Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

: 100-44-7
benzyl chloride

: 628717-07-7
(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]piperazine-2,5-dione

: 628717-16-8
(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: (Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]piperazine-2,5-dione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

benzyl chloride; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1248/cpb.51.821

Reference yield:

: 310903-92-5
(Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 628717-16-8
(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / Rh/C / methanol / 1 h / 760 Torr

2.1: 76.6 percent / pyridine; DMAP / 1 h / 25 °C

3.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; Rh on carbon; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 628717-16-8
(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91.2 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

With potassium tert-butylate; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821