(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Base Information

Chemical Name:(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione
CAS No.:628717-23-7
Molecular Formula:C₃₉H₃₉BrN₂O₉S
Molecular Weight:791.717
Hs Code.:

(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Synonyms:(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

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Chemical Property of (Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

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Technology Process of (Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

There total 8 articles about (Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

: 628717-16-8
(Z)-1-acetyl-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

: 628717-23-7
(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: With potassium carbonate; In methanol; at 25 ℃; for 2h;
DOI:10.1248/cpb.51.821

Reference yield:

: 310903-92-5
(Z)-1-acetyl-3-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethylene)-2,5-piperazinedione

: 628717-23-7
(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂ / Rh/C / methanol / 1 h / 760 Torr

2.1: 76.6 percent / pyridine; DMAP / 1 h / 25 °C

3.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

4.1: NaH / dimethylformamide / 0.5 h / 0 °C

4.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

5.1: 66.2 percent / K₂CO₃ / methanol / 2 h / 25 °C

With pyridine; dmap; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; Rh on carbon; In methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 628717-23-7
(Z)-6-(2-bromo-5-isopropoxy-4-methoxy-3-methylphenylmethyl)-3-[3-methyl-2-(4-methylbenzenesulfoxy)-4,5-methylenedioxyphenylidene]-4-phenylmethylpiperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91.2 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2.1: 78 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; dimethylformamide / 4 h / 25 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 87.9 percent / dimethylformamide / 24 h / 25 °C

4.1: 66.2 percent / K₂CO₃ / methanol / 2 h / 25 °C

With potassium tert-butylate; sodium hydride; potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.51.821