N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide

Base Information

• Chemical Name: N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide
• CAS No.: 120824-79-5
• Molecular Formula: C₂₀H₂₁N₃O₇
• Molecular Weight: 415.403
• Mol file: 120824-79-5.mol

Synonyms:N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide

Chemical Property of N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide

There total 2 articles about N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

N-benzyloxycarbonyl-γ-carboxy-DL-glutamic acid (97458-26-9) + phenylhydrazine (100-63-0) → N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide (120824-79-5)

Guidance literature:

With papaine; In water; at 38 ℃; for 24h; ethylenediaminetetraacetic acid, cysteine hydrochloride, pH 4.8;

Reference yield:

diethyl benzyloxycarbonyl-γ-carboxy-DL-pyroglutamate (120824-81-9) → N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide (120824-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / NaOH / methanol; H₂O / 3 h / Ambient temperature

2: 39 percent / papaine / H₂O / 24 h / 38 °C / ethylenediaminetetraacetic acid, cysteine hydrochloride, pH 4.8

With sodium hydroxide; papaine; In methanol; water;

Reference yield: 72.0%

N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid α-phenylhydrazide (120824-79-5) → N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid (97458-26-9,120824-82-0)

Guidance literature:

With iron(III) chloride; In 1,4-dioxane; water; at 35 ℃; for 0.666667h;

upstream raw materials:

N-benzyloxycarbonyl-γ-carboxy-DL-glutamic acid

phenylhydrazine

diethyl benzyloxycarbonyl-γ-carboxy-DL-pyroglutamate

Downstream raw materials:

N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid

γ-carboxy-L-glutamic acid