ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Base Information

Chemical Name:ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
CAS No.:863290-94-2
Molecular Formula:C₁₇H₁₇N₃O₅
Molecular Weight:343.339
Hs Code.:

Synonyms:ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

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Chemical Property of ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

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Technology Process of ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

There total 1 articles about ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 105-53-3
diethyl malonate

: 383911-62-4
5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 863290-94-2
ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Guidance literature:: diethyl malonate; With sodium ethanolate; In ethanol; at 20 ℃; for 0.25h;

5-amino-1-(2-hydroxy-2-phenylethyl)-1H-pyrazole-4-carboxylic acid ethyl ester; In ethanol; for 6h; Heating;
DOI:10.1039/b502831k

Reference yield: 54.0%

: 863290-94-2
ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 863290-95-3
ethyl 4-chloro-1-(2-chloro-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In chloroform; for 3h; Heating;
DOI:10.1039/b502831k

Reference yield:

: 863290-94-2
ethyl 4-hydroxy-1-(2-hydroxy-2-phenylethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1-(2-chloro-2-phenyl-ethyl)-6-oxo-4-pyrrolidin-1-yl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / SOCl₂; DMF / CHCl₃ / 3 h / Heating

2: 68 percent / glacial acetic acid / dioxane / 0.17 h / 150 °C / 1810.02 Torr / microwave irradiation

With thionyl chloride; acetic acid; N,N-dimethyl-formamide; In 1,4-dioxane; chloroform;
DOI:10.1039/b502831k