methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

Base Information

Chemical Name:methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate
CAS No.:1202273-68-4
Molecular Formula:C₂₄H₂₄N₄O₂
Molecular Weight:400.48
Hs Code.:

Synonyms:methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

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Chemical Property of methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

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Technology Process of methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

There total 4 articles about methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 288-88-0
1,2,4-Triazole

: 1202273-88-8
3-hydroxy-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propionic acid methyl ester

: 1202273-68-4
methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

Guidance literature:: With 1,1'-Carbonyl-di-(1,2,4-triazole); In acetonitrile; for 16h; Reflux;
DOI:10.1021/jm200695m

Reference yield:

: methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate

: 1202273-68-4
methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 0.5 h

2.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C / Molecular sieve

3.1: thionyl chloride / acetonitrile / 1 h / 0 - 10 °C / Inert atmosphere

3.2: 72 h / 20 °C

With pyridine; thionyl chloride; hydrogen; copper diacetate; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile; 2.1: Suzuki Coupling;

Reference yield:

: 1202273-87-7
3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 1202273-68-4
methyl 2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]-3-(1H-1,2,4-triazol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; copper diacetate / dichloromethane / 72 h / 20 °C / Molecular sieve

2.1: thionyl chloride / acetonitrile / 1 h / 0 - 10 °C / Inert atmosphere

2.2: 72 h / 20 °C

With pyridine; thionyl chloride; copper diacetate; In dichloromethane; acetonitrile; 1.1: Suzuki Coupling;