C₂₂H₂₃NO₃

Base Information

Chemical Name:C₂₂H₂₃NO₃
CAS No.:1452815-92-7
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

C<sub>22</sub>H<sub>23</sub>NO<sub>3</sub>

Synonyms:C₂₂H₂₃NO₃

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Chemical Property of C₂₂H₂₃NO₃

Chemical Property:

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Technology Process of C₂₂H₂₃NO₃

There total 9 articles about C₂₂H₂₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1452815-91-6
C₂₂H₂₄N₂O₃

: 1452815-92-7
C₂₂H₂₃NO₃

Guidance literature:: With sodium hydrogen sulfate; acetic acid; sodium nitrite; In ethanol; at 20 ℃; for 3h; stereoselective reaction;
DOI:10.1016/j.tetlet.2013.07.115

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 1452815-92-7
C₂₂H₂₃NO₃

Guidance literature:: Multi-step reaction with 7 steps

1: titanium(IV) isopropylate / toluene / 12 h / 100 °C

2: zinc(II) chloride / diethyl ether / -78 - 25 °C

3: potassium hydroxide; water / methanol / Reflux

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C

5: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C

6: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

7: sodium nitrite; sodium hydrogen sulfate; acetic acid / ethanol / 3 h / 20 °C

With titanium(IV) isopropylate; sodium hydrogen sulfate; 15-crown-5; tin(II) chloride dihdyrate; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2013.07.115

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 1452815-92-7
C₂₂H₂₃NO₃

Guidance literature:: Multi-step reaction with 8 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 0 - 30 °C

2: titanium(IV) isopropylate / toluene / 12 h / 100 °C

3: zinc(II) chloride / diethyl ether / -78 - 25 °C

4: potassium hydroxide; water / methanol / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C

6: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C

7: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux

8: sodium nitrite; sodium hydrogen sulfate; acetic acid / ethanol / 3 h / 20 °C

With titanium(IV) isopropylate; aluminum (III) chloride; sodium hydrogen sulfate; 15-crown-5; tin(II) chloride dihdyrate; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; 1: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2013.07.115