(3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine

Base Information

• Chemical Name: (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine
• CAS No.: 862672-25-1
• Molecular Formula: C₂₃H₂₆N₂O₂
• Molecular Weight: 362.472
• Mol file: 862672-25-1.mol

Synonyms:(3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine

Chemical Property of (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine

There total 2 articles about (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine (862672-24-0) + allyl-trimethyl-silane (762-72-1) → (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine (862672-25-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -15 ℃; for 24h;

DOI:10.1021/ja052307+

Reference yield:

(E)-N'-(3-phenylpropylidene)benzohydrazide → (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine (862672-25-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / (S,S)-phenylsilane derivative / toluene / 24 h / 23 °C

2: 99 percent / DMAP; pyridine / CH₂Cl₂ / 0 - 20 °C

3: 65 percent / TMSOTf / CH₂Cl₂ / 24 h / -15 °C

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; (S,S)-phenylsilane derivative; In dichloromethane; toluene;

DOI:10.1021/ja052307+

Reference yield: 87.0%

(3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine (862672-25-1) → (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine

Guidance literature:

With methanol; samarium diiodide; In tetrahydrofuran; for 0.5h;

DOI:10.1021/ja052307+

upstream raw materials:

(3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine

allyl-trimethyl-silane