(3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine

Base Information

• Chemical Name: (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine
• CAS No.: 862672-24-0
• Molecular Formula: C₂₄H₃₀N₂O₃
• Molecular Weight: 394.514
• Mol file: 862672-24-0.mol

Synonyms:(3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine

Chemical Property of (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine

There total 2 articles about (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl vinyl ether (926-02-3) → (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine (862672-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / (S,S)-phenylsilane derivative / toluene / 24 h / 23 °C

2: 99 percent / DMAP; pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; dmap; (S,S)-phenylsilane derivative; In dichloromethane; toluene;

DOI:10.1021/ja052307+

Reference yield:

(E)-N'-(3-phenylpropylidene)benzohydrazide → (3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine (862672-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / (S,S)-phenylsilane derivative / toluene / 24 h / 23 °C

2: 99 percent / DMAP; pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; dmap; (S,S)-phenylsilane derivative; In dichloromethane; toluene;

DOI:10.1021/ja052307+

Reference yield: 65.0%

(3R,5R)-2-(acetyl)-1-(benzoyl)-5-(tert-butoxy)-3-(phenethyl)pyrazolidine (862672-24-0) + allyl-trimethyl-silane (762-72-1) → (3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine (862672-25-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -15 ℃; for 24h;

DOI:10.1021/ja052307+

upstream raw materials:

tert-butyl vinyl ether

Downstream raw materials:

(3R,5R)-2-(acetyl)-5-(allyl)-1-(benzoyl)-3-(phenethyl)pyrazolidine