(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Base Information

Chemical Name:(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine
CAS No.:937724-05-5
Molecular Formula:C₂₉H₃₆N₂O
Molecular Weight:428.618
Hs Code.:

Synonyms:(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

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Chemical Property of (2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Chemical Property:

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Technology Process of (2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

There total 6 articles about (2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 858674-01-8
(2'-methoxy-4-biphenyl)methylamine

: 937724-02-2
[1-(4-methylbenzyl)-4-piperidinyl]acetaldehyde

: 937724-05-5
(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Guidance literature:: (2'-methoxy-4-biphenyl)methylamine; [1-(4-methylbenzyl)-4-piperidinyl]acetaldehyde; With molecular sieve; In methanol; at 20 ℃; for 12h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; Further stages.;
DOI:10.1016/j.bmc.2007.02.049

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 937724-05-5
(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / K₂CO₃ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / acetonitrile / 8 h / Heating

2.1: molecular sieves / methanol / 12 h / 20 °C

2.2: 70 percent / sodium triacetoxyborohydride / methanol / 20 °C

With molecular sieve; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2007.02.049

Reference yield:

: 5720-06-9
2-Methoxyphenylboronic acid

: 937724-05-5
(2'-methoxy-4-biphenylmethyl)-{2-[1-(4-methylbenzyl)-4-piperidinyl]ethyl}amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 80 percent / K₂CO₃ / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / acetonitrile / 8 h / Heating

2.1: molecular sieves / methanol / 12 h / 20 °C

2.2: 70 percent / sodium triacetoxyborohydride / methanol / 20 °C

With molecular sieve; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetonitrile; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2007.02.049