4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

Base Information

Chemical Name:4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine
CAS No.:1312290-93-9
Molecular Formula:C₁₇H₂₆N₄O₃
Molecular Weight:334.418
Hs Code.:

Synonyms:4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

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Chemical Property of 4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

Chemical Property:

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Technology Process of 4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

There total 6 articles about 4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1312290-89-3
[3-methyl-2-(4-methylpiperazino)-5-nitrophenyl]methanamine

: 111-44-4
3-oxa-1,5-dichloropentane

: 1312290-93-9
4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 48h; Reflux;

Reference yield:

: 1312290-85-9
2-[(2-bromo-3-methyl-5-nitrophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

: 1312290-93-9
4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / acetonitrile / Reflux

1.3: pH 10

2.1: tetrahydrofuran

3.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

4.1: acetyl chloride; methanol / 2 h / 20 °C

4.2: pH 10

5.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

With methanol; potassium carbonate; caesium carbonate; hydrazine hydrate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 7149-70-4
2-bromo-5-nitrotoluene

: 1312290-93-9
4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluorormethanesulfonic acid / 0.33 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrazine hydrate / acetonitrile / Reflux

2.3: pH 10

3.1: tetrahydrofuran

4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

5.1: acetyl chloride; methanol / 2 h / 20 °C

5.2: pH 10

6.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

With methanol; trifluorormethanesulfonic acid; potassium carbonate; caesium carbonate; hydrazine hydrate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; acetonitrile;