((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

Base Information

Chemical Name:((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane
CAS No.:1044572-87-3
Molecular Formula:C₂₄H₂₃ClO₂SSi
Molecular Weight:439.05
Hs Code.:

Synonyms:((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

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Chemical Property of ((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

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Technology Process of ((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

There total 4 articles about ((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1044572-75-9
({4-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

: 1044572-87-3
((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

Guidance literature:: ({4-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -30 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at -30 - 25 ℃; Inert atmosphere;

1-Chloro-4-iodobenzene; With (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; In tetrahydrofuran; at 50 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol801431z

Reference yield:

: 31401-23-7
p-methoxybenzenesulfinyl chloride

: 1044572-87-3
((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: -50 - 25 °C / Inert atmosphere

2.1: isopropylmagnesium bromide / tetrahydrofuran / 25 - 60 °C / Inert atmosphere

2.2: 0.5 h / 25 °C / Inert atmosphere

2.3: 14 h / 25 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

3.2: 25 °C / Inert atmosphere

3.3: 3 h / 50 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; isopropylmagnesium bromide; In tetrahydrofuran;
DOI:10.1002/chem.201003657

Reference yield:

: 1044572-73-7
4-iodophenyl 4'-methoxyphenyl sulfoxide

: 1044572-87-3
((4'-chloro-6-((4-methoxyphenyl)sulfinyl)-[1,1'-biphenyl]-3-yl)ethynyl)trimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium bromide / tetrahydrofuran / 25 - 60 °C / Inert atmosphere

1.2: 0.5 h / 25 °C / Inert atmosphere

1.3: 14 h / 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

2.3: 3 h / 50 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; isopropylmagnesium bromide; In tetrahydrofuran;
DOI:10.1002/chem.201003657