N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

Base Information

• Chemical Name: N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester
• CAS No.: 52498-40-5
• Molecular Formula: C₂₁H₂₃N₃O₉
• Molecular Weight: 461.428
• Mol file: 52498-40-5.mol

Synonyms:N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

Chemical Property of N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

There total 1 articles about N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-3-methylacetophenone (10024-90-5) → N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester (52498-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOOH, NaOAc / acetic acid

2: (i) SOCl₂, Py, (ii) /BRN= 2043682/

With peracetic acid; sodium acetate; In acetic acid;

DOI:10.1021/jm00250a014

Reference yield:

N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester (52498-40-5) → 3,5,3'-Trimethyl-L-thyronin (52050-08-5)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) (reduction), (ii) (diazotization), (iii) I₂, aq. KI

2: Py / Heating

3: H₂, 1-isopropyl-4-methyl-benzene / Pd-C

4: aq. HI / acetic acid / Heating

With pyridine; 4-methylisopropylbenzene; hydrogen iodide; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00250a014

Reference yield:

N-Acetyl-3,5-dinitro-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester (52498-40-5) → N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester (52498-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) (reduction), (ii) (diazotization), (iii) I₂, aq. KI

2: Py / Heating

3: H₂, 1-isopropyl-4-methyl-benzene / Pd-C

With pyridine; 4-methylisopropylbenzene; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00250a014

upstream raw materials:

4-methoxy-3-methylacetophenone

Downstream raw materials:

N-Acetyl-3,5-diiod-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

3,5,3'-Trimethyl-L-thyronin

N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester

N-Acetyl-3.5-dicyano-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninaethylester