N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

Base Information

Chemical Name:N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide
CAS No.:1123580-75-5
Molecular Formula:C₂₄H₁₉FN₄O₂S
Molecular Weight:446.505
Hs Code.:

Synonyms:N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

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Chemical Property of N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

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Technology Process of N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

There total 4 articles about N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1123580-73-3
N-[3-(4-amino-2-fluorophenoxy)phenyl]-3-(2-cyanopropan-2-yl)benzamide

: 333-20-0
potassium thioacyanate

: 1123580-75-5
N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

Guidance literature:: potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

N-[3-(4-amino-2-fluorophenoxy)phenyl]-3-(2-cyanopropan-2-yl)benzamide; With acetic acid; at 20 ℃; for 0.25h;

Reference yield:

: 1123580-71-1
3-(1-cyano-1-methylethyl)-N-[3-(2-fluoro-4-nitrophenoxy)phenyl]benzamide

: 1123580-75-5
N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: calcium chloride; iron / water; ethanol / 12 h / Reflux

2.1: acetic acid / 20 °C

2.2: 20 °C

With iron; acetic acid; calcium chloride; In ethanol; water;
DOI:10.1021/jm400778d

Reference yield:

: 1092395-04-4
3-(1-cyano-1-methylethyl)-N-(3-hydroxyphenyl)benzamide

: 1123580-75-5
N-{3-[(2-amino-5-fluoro-1,3-benzothiazol-6-yl)oxy]phenyl}-3-(2-cyanopropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: calcium chloride; iron / water; ethanol / 12 h / Reflux

3.1: acetic acid / 20 °C

3.2: 20 °C

With iron; potassium carbonate; acetic acid; calcium chloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400778d