N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide

Base Information

• Chemical Name: N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide
• CAS No.: 1259947-22-2
• Molecular Formula: C₂₁H₂₅N₅O₃S
• Molecular Weight: 427.527
• Mol file: 1259947-22-2.mol

Synonyms:N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide

Chemical Property of N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide

There total 10 articles about N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzyloxycarbonyl)leucine 1,2-dimethylhydrazide (1043922-51-5) → N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide (1259947-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr

2: dichloromethane / 18 h / 20 °C

With 10% palladium on activated charcoal; hydrogen; In methanol; dichloromethane;

DOI:10.1021/jm101272p

Reference yield:

Z-Leu-OH (2018-66-8) → N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide (1259947-22-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C

2: sodium hydroxide / tetrahydrofuran; water / -25 - 20 °C

3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr

4: dichloromethane / 18 h / 20 °C

With 4-methyl-morpholine; 10% palladium on activated charcoal; hydrogen; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jm101272p

Reference yield:

C17H16N2O3S → N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide (1259947-22-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C

3: dichloromethane / 18 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm101272p

upstream raw materials:

N-(benzyloxycarbonyl)leucine 1,2-dimethylhydrazide

Z-Leu-OH

C₁₂H₁₆N₂O₃

4-[(2-thiophenecarbonyl)oxyamidino]benzoic acid tert-butyl ester

Downstream raw materials:

N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile