N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

Base Information

Chemical Name:N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile
CAS No.:1259946-02-5
Molecular Formula:C₂₂H₂₄N₆O₃S
Molecular Weight:452.537
Hs Code.:

Synonyms:N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

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Chemical Property of N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

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Technology Process of N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

There total 11 articles about N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 506-68-3
bromocyane

: 1259947-22-2
N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucine 1,2-dimethylhydrazide

: 1259946-02-5
N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

Guidance literature:: With sodium acetate; In methanol; at 20 ℃; for 48h;
DOI:10.1021/jm101272p

Reference yield:

: 1043922-51-5
N-(benzyloxycarbonyl)leucine 1,2-dimethylhydrazide

: 1259946-02-5
N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr

2: dichloromethane / 18 h / 20 °C

3: sodium acetate / methanol / 48 h / 20 °C

With 10% palladium on activated charcoal; hydrogen; sodium acetate; In methanol; dichloromethane;
DOI:10.1021/jm101272p

Reference yield:

: 2018-66-8
Z-Leu-OH

: 1259946-02-5
N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C

2: sodium hydroxide / tetrahydrofuran; water / -25 - 20 °C

3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr

4: dichloromethane / 18 h / 20 °C

5: sodium acetate / methanol / 48 h / 20 °C

With 4-methyl-morpholine; 10% palladium on activated charcoal; hydrogen; sodium acetate; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm101272p