Technology Process of N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile
There total 11 articles about N-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]benzoyl}-leucyl-methylazaalanine-nitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium acetate;
In
methanol;
at 20 ℃;
for 48h;
DOI:10.1021/jm101272p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr
2: dichloromethane / 18 h / 20 °C
3: sodium acetate / methanol / 48 h / 20 °C
With
10% palladium on activated charcoal; hydrogen; sodium acetate;
In
methanol; dichloromethane;
DOI:10.1021/jm101272p
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 °C
2: sodium hydroxide / tetrahydrofuran; water / -25 - 20 °C
3: 10% palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 1500.15 Torr
4: dichloromethane / 18 h / 20 °C
5: sodium acetate / methanol / 48 h / 20 °C
With
4-methyl-morpholine; 10% palladium on activated charcoal; hydrogen; sodium acetate; sodium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm101272p
